The 777-200LR ("LR" for Longer Range), the C-market model, became the world's longest-range commercial airliner when it entered service in 2006. Boeing named this aircraft the Worldliner, highlighting its ability to connect almost any two airports in the world, although it is still subject to ETOPS restrictions. It holds the world record for the longest nonstop flight by a commercial airliner, and has a maximum design range of 9,395 nautical miles (17,400 km). The -200LR was intended for ultra-long-haul routes such as Los Angeles to Singapore.

Developed alongside the -300ER, the -200LR features an increased MTOW and three optional auxiliary fuel tanks in the rear cargo hold. Other new features include raked wingtips, redesigned main landing gear, and additional structural strengthening. As with the -300ER and 777F, the -200LR is equipped with wingtip extensions of 12.8 ft (3.90 m). The -200LR is powered by GE90-110B1 or GE90-115B turbofans. The first -200LR was delivered to Pakistan International Airlines on February 26, 2006. As of February 2013, nine different -200LR customers have taken delivery of 55 aircraft, with 3 unfilled orders.